Check out this sweet Fuel Efficient routing we plugged into the truck load board. Now when you are finding freight you can see if the rout you would take it red or Green. The green means that it is the most fuel efficient route you can take. This is pretty sweet way to negotiate the truckload with the carrier or the shipper.
If your route is all up hill then as a carrier you need to get more per mile and if the route is all down hill you can negotiate your way to a better rate per mile.